InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POLI

Summary

InnateDB Protein

IDBP-727323.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLI

Protein Name

Synonyms

RAD30B; RAD3OB;

Species

Homo sapiens

Ensembl Protein

ENSP00000462664

InnateDB Gene

IDBG-3542 (POLI)

Protein Structure

UniProt Annotation

Function

Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity. {ECO:0000269PubMed:11013228, ECO:0000269PubMed:11251121, ECO:0000269PubMed:11387224, ECO:0000269PubMed:12410315, ECO:0000269PubMed:14630940, ECO:0000269PubMed:15199127, ECO:0000269PubMed:15254543}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12606586}. Note=Accumulates at replication forks after DNA damage.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in testis. {ECO:0000269PubMed:10458907, ECO:0000269PubMed:11387224}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0005515	protein binding
GO:0046872	metal ion binding