InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SIRT7

Summary

InnateDB Protein

IDBP-72841.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIRT7

Protein Name

sirtuin 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000329466

InnateDB Gene

IDBG-72839 (SIRT7)

Protein Structure

UniProt Annotation

Function

NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation. {ECO:0000269PubMed:16618798, ECO:0000269PubMed:19174463, ECO:0000269PubMed:22722849}.

Subcellular Localization

Cytoplasm. Nucleus, nucleolus. Note=Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 663 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	663 [view]
Protein-Protein	663 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0070403	NAD+ binding
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0007072	positive regulation of transcription on exit from mitosis
GO:0009303	rRNA transcription
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation