InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACVR1C

Summary

InnateDB Protein

IDBP-72898.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACVR1C

Protein Name

activin A receptor, type IC

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000243349

InnateDB Gene

IDBG-72896 (ACVR1C)

Protein Structure

UniProt Annotation

Function

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. {ECO:0000269PubMed:12063393, ECO:0000269PubMed:15531507}.

Subcellular Localization

Membrane {ECO:0000269PubMed:12606401}; Single-pass type I membrane protein {ECO:0000269PubMed:12606401}.

Disease Associations

Tissue Specificity

Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy. {ECO:0000269PubMed:12063393, ECO:0000269PubMed:12606401}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005524	ATP binding
GO:0016361	activin receptor activity, type I
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0038100	nodal binding
GO:0046872	metal ion binding

Biological Process

GO:0002021	response to dietary excess
GO:0006468	protein phosphorylation
GO:0009749	response to glucose
GO:0019915	lipid storage
GO:0023014	signal transduction by phosphorylation
GO:0030154	cell differentiation
GO:0030262	apoptotic nuclear changes
GO:0032868	response to insulin
GO:0038092	nodal signaling pathway
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046676	negative regulation of insulin secretion
GO:1901164	negative regulation of trophoblast cell migration
GO:1901383	negative regulation of chorionic trophoblast cell proliferation

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0048179	activin receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003605 TGF beta receptor, GS motif
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF01064
PF00069
PF07714
PF08515

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00467
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt