InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACVR1C

Summary

InnateDB Gene

IDBG-72896.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACVR1C

Gene Name

activin A receptor, type IC

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000123612

Encoded Proteins

IDBP-72898

activin A receptor, type IC

IDBP-72900

activin A receptor, type IC

IDBP-72902

activin A receptor, type IC

IDBP-293953

activin A receptor, type IC

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:157526767-157629005

Strand

Reverse strand

Band

q24.1

Transcripts

ENST00000243349	ENSP00000243349
ENST00000335450	ENSP00000335178
ENST00000348328	ENSP00000335139
ENST00000409680	ENSP00000387168

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005524	ATP binding
GO:0016361	activin receptor activity, type I
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0038100	nodal binding
GO:0046872	metal ion binding

Biological Process

GO:0002021	response to dietary excess
GO:0006468	protein phosphorylation
GO:0009749	response to glucose
GO:0019915	lipid storage
GO:0023014	signal transduction by phosphorylation
GO:0030154	cell differentiation
GO:0030262	apoptotic nuclear changes
GO:0032868	response to insulin
GO:0038092	nodal signaling pathway
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046676	negative regulation of insulin secretion
GO:1901164	negative regulation of trophoblast cell migration
GO:1901383	negative regulation of chorionic trophoblast cell proliferation

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0048179	activin receptor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026834

View Gene Order

ENSBTAG00000019337

Not yet available

Pathways

NETPATH

REACTOME

REACT_150238

Signaling by Activin pathway

REACT_111059

Regulation of signaling by NODAL pathway

REACT_111057

Signaling by NODAL pathway

REACT_111045

Developmental Biology pathway

REACT_111102

Signal Transduction pathway

KEGG

hsa04350

TGF-beta signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.562901 Hs.627332

RefSeq

NM_001111031 NM_001111032 NM_001111033 NM_145259

HUGO

OMIM

CCDS

CCDS2205 CCDS46432 CCDS46433 CCDS46434

HPRD

10608

IMGT

EMBL

GenPept

RNA Seq Atlas