InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLA2

Summary

InnateDB Protein

IDBP-73006.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLA2

Protein Name

Src-like-adaptor 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000262866

InnateDB Gene

IDBG-73000 (SLA2)

Protein Structure

UniProt Annotation

Function

Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269PubMed:11696592}.

Subcellular Localization

Cytoplasm.Isoform 1: Cell membrane. Cytoplasmic vesicle. Note=Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.Isoform 2: Cytoplasm {ECO:0000305}. Note=May be cytoplasmic and is not localized to membranes.

Disease Associations

Tissue Specificity

Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0009967	positive regulation of signal transduction
GO:0019724	B cell mediated immunity
GO:0030522	intracellular receptor signaling pathway
GO:0042110	T cell activation
GO:0050776	regulation of immune response
GO:0050849	negative regulation of calcium-mediated signaling
GO:0050851	antigen receptor-mediated signaling pathway
GO:0050869	negative regulation of B cell activation