Version 5.4
Homo sapiens Gene: SLA2
Summary
InnateDB Gene IDBG-73000.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLA2
Gene Name Src-like-adaptor 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101082
Encoded Proteins
IDBP-73006
Src-like-adaptor 2
IDBP-73008
Src-like-adaptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:36612318-36646216
Strand Reverse strand
Band q11.23
Transcripts
ENST00000262866 ENSP00000262866
ENST00000360672 ENSP00000353890
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0009967 positive regulation of signal transduction
GO:0019724 B cell mediated immunity
GO:0030522 intracellular receptor signaling pathway
GO:0042110 T cell activation
GO:0050776 regulation of immune response
GO:0050849 negative regulation of calcium-mediated signaling
GO:0050851 antigen receptor-mediated signaling pathway
GO:0050869 negative regulation of B cell activation
Cellular Component
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027636
View Gene Order
ENSBTAG00000040607
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
NetPath_12
BCR pathway
REACTOME
KEGG
INOH
PID NCI
tcr_pathway
TCR signaling in naïve CD4+ T cells
Cross-References
SwissProt Q9H6Q3
TrEMBL
UniProt Splice Variant
Entrez Gene 84174
UniGene Hs.713578
RefSeq NM_175077 NM_032214
HUGO HGNC:17329
OMIM 606577
CCDS CCDS13283 CCDS13282
HPRD 05955
IMGT
EMBL AF290985 AF290986 AF326353 AK025645 AK291513 AL031662 AL050318 BC042041 CH471077
GenPept AAH42041 AAL29204 AAL38197 AAL38198 BAB15201 BAF84202 CAI21397 CAI21398 CAI23504 CAI23505 EAW76116 EAW76117 EAW76118 EAW76119
RNA Seq Atlas 84174

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca