InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DCXR

Summary

InnateDB Protein

IDBP-73077.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCXR

Protein Name

dicarbonyl/L-xylulose reductase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000303356

InnateDB Gene

IDBG-73075 (DCXR)

Protein Structure

UniProt Annotation

Function

Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.

Subcellular Localization

Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Probably recruited to membranes via an interaction with phosphatidylinositol. {ECO:0000250}.

Disease Associations

Pentosuria (PNTSU) [MIM:260800]: An inborn error of metabolism characterized by excessive urinary excretion of L- xylulose. {ECO:0000269PubMed:11882650, ECO:0000269PubMed:22042873, ECO:0000269PubMed:4392213}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis. {ECO:0000269PubMed:10385429, ECO:0000269PubMed:11882650}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016491	oxidoreductase activity
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0050038	L-xylulose reductase (NADP+) activity

Biological Process

GO:0005997	xylulose metabolic process
GO:0006006	glucose metabolic process
GO:0006739	NADP metabolic process
GO:0008152	metabolic process
GO:0042732	D-xylose metabolic process
GO:0051289	protein homotetramerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005881	cytoplasmic microtubule
GO:0005902	microvillus
GO:0005903	brush border
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR

PFAM

PF00106
PF08659

PRINTS

PR00080
PR00081
PR01397

PIRSF

PIRSF000126

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt