Version 5.4
Homo sapiens Gene: DCXR
Summary
InnateDB Gene IDBG-73075.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCXR
Gene Name dicarbonyl/L-xylulose reductase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000169738
Encoded Proteins
IDBP-73077
dicarbonyl/L-xylulose reductase
IDBP-757750
IDBP-764295
IDBP-758582
IDBP-763283
IDBP-758604
IDBP-763647
IDBP-761290
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:82035136-82037732
Strand Reverse strand
Band q25.3
Transcripts
ENST00000306869 ENSP00000303356
ENST00000585085
ENST00000578885
ENST00000581584 ENSP00000464507
ENST00000582613
ENST00000579004 ENSP00000464332
ENST00000580320
ENST00000582074
ENST00000584318
ENST00000577712 ENSP00000462725
ENST00000582900 ENSP00000462272
ENST00000579334
ENST00000577996
ENST00000577286
ENST00000577532 ENSP00000463354
ENST00000578273
ENST00000585164
ENST00000579821 ENSP00000464518
ENST00000579155 ENSP00000462226
ENST00000580750
ENST00000579842
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0050038 L-xylulose reductase (NADP+) activity
Biological Process
GO:0005997 xylulose metabolic process
GO:0006006 glucose metabolic process
GO:0006739 NADP metabolic process
GO:0008152 metabolic process
GO:0042732 D-xylose metabolic process
GO:0051289 protein homotetramerization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005881 cytoplasmic microtubule
GO:0005902 microvillus
GO:0005903 brush border
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039450
View Gene Order
ENSBTAG00000008747
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00040
Pentose and glucuronate interconversions pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001195218 NM_016286
HUGO
OMIM
CCDS CCDS11799
HPRD 16320
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca