InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PCSK7

Summary

InnateDB Protein

IDBP-73101.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCSK7

Protein Name

proprotein convertase subtilisin/kexin type 7

Synonyms

LPC; PC7; PC8; SPC7;

Species

Homo sapiens

Ensembl Protein

ENSP00000325917

InnateDB Gene

IDBG-73097 (PCSK7)

Protein Structure

UniProt Annotation

Function

Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Seems to be localized intracellularly to the trans Golgi network. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity
GO:0008233	peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0016485	protein processing
GO:0016486	peptide hormone processing

Cellular Component

GO:0030173

integral component of Golgi membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000209 Peptidase S8/S53 domain
IPR002884 Proprotein convertase, P
IPR008979 Galactose-binding domain-like
IPR009020 Proteinase inhibitor, propeptide
IPR015500 Peptidase S8, subtilisin-related

PFAM

PF00082
PF01483

PRINTS

PR00723

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q16549