InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RFNG

Summary

InnateDB Protein

IDBP-73121.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RFNG

Protein Name

RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000307971

InnateDB Gene

IDBG-73119 (RFNG)

Protein Structure

UniProt Annotation

Function

Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. May be involved in limb formation and in neurogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0016757	transferase activity, transferring glycosyl groups
GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0007389	pattern specification process
GO:0007399	nervous system development
GO:0008152	metabolic process
GO:0009887	organ morphogenesis
GO:0030154	cell differentiation
GO:0032092	positive regulation of protein binding
GO:0045747	positive regulation of Notch signaling pathway