Homo sapiens Protein: PLA2R1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-73345.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PLA2R1 | ||||||||||||||||||
Protein Name | phospholipase A2 receptor 1, 180kDa | ||||||||||||||||||
Synonyms | CLEC13C; PLA2-R; PLA2G1R; PLA2IR; PLA2R; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000283243 | ||||||||||||||||||
InnateDB Gene | IDBG-73343 (PLA2R1) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2- IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow- derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B. {ECO:0000269PubMed:15611272, ECO:0000269PubMed:7721806}. | ||||||||||||||||||
Subcellular Localization | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.Soluble secretory phospholipase A2 receptor: Secreted {ECO:0000250}.Isoform 2: Secreted {ECO:0000305}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level. {ECO:0000269PubMed:15611272, ECO:0000269PubMed:7721806, ECO:0000269PubMed:7925459, ECO:0000269PubMed:9481783}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000562
Fibronectin, type II, collagen-binding IPR000772 Ricin B lectin domain IPR001304 C-type lectin IPR013806 Kringle-like fold IPR016187 C-type lectin fold |
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PFAM |
PF00040
PF00652 PF14200 PF00059 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00059
SM00458 SM00034 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q13018 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q13018 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 22925 | ||||||||||||||||||
UniGene | Hs.410477 | ||||||||||||||||||
RefSeq | NP_031392 | ||||||||||||||||||
HUGO | HGNC:9042 | ||||||||||||||||||
OMIM | 604939 | ||||||||||||||||||
CCDS | CCDS33309 | ||||||||||||||||||
HPRD | 09222 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC080166 AC093873 BC140823 CH471058 D30780 U17033 U17034 | ||||||||||||||||||
GenPept | AAA70110 AAC50163 AAI40824 AAY24052 AAY24190 BAA06444 EAX11392 EAX11393 | ||||||||||||||||||