InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RASEF

Summary

InnateDB Protein

IDBP-73401.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASEF

Protein Name

RAS and EF-hand domain containing

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000365630

InnateDB Gene

IDBG-73397 (RASEF)

Protein Structure

UniProt Annotation

Function

Binds predominantly GDP, and also GTP. {ECO:0000269PubMed:17448446}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:17448446}.

Disease Associations

Tissue Specificity

Down-regulated in cutaneous melanoma cells but not in breast cancer cells. {ECO:0000269PubMed:16174859}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005509	calcium ion binding
GO:0005525	GTP binding
GO:0051015	actin filament binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport

Cellular Component

GO:0005622	intracellular
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR002048 EF-hand domain
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006077 Vinculin/alpha-catenin
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM