Version 5.4
Homo sapiens Protein: RASEF
Summary
InnateDB Protein IDBP-73403.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RASEF
Protein Name RAS and EF-hand domain containing
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000345651
InnateDB Gene IDBG-73397 (RASEF)
Protein Structure
UniProt Annotation
Function Binds predominantly GDP, and also GTP. {ECO:0000269PubMed:17448446}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000269PubMed:17448446}.
Disease Associations
Tissue Specificity Down-regulated in cutaneous melanoma cells but not in breast cancer cells. {ECO:0000269PubMed:16174859}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005525 GTP binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
Cellular Component
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IZ41
PhosphoSite PhosphoSite-Q8IZ41
TrEMBL
UniProt Splice Variant
Entrez Gene 158158
UniGene Hs.715184
RefSeq
HUGO HGNC:26464
OMIM 611344
CCDS
HPRD 08337
IMGT
EMBL AK056176 AL499602 BC023566 CH471089
GenPept AAH23566 CAH70678 CAH70679 EAW62643

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca