InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC27A5

Summary

InnateDB Protein

IDBP-73445.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC27A5

Protein Name

solute carrier family 27 (fatty acid transporter), member 5

Synonyms

ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5; FATP5; VLACSR; VLCS-H2; VLCSH2;

Species

Homo sapiens

Ensembl Protein

ENSP00000263093

InnateDB Gene

IDBG-73443 (SLC27A5)

Protein Structure

UniProt Annotation

Function

Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. {ECO:0000269PubMed:10749848, ECO:0000269PubMed:11980911}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:10479480}; Multi-pass membrane protein {ECO:0000269PubMed:10479480}.

Disease Associations

Tissue Specificity

Predominantly expressed in liver. {ECO:0000269PubMed:10479480}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005524	ATP binding
GO:0015245	fatty acid transporter activity
GO:0031957	very long-chain fatty acid-CoA ligase activity
GO:0032403	protein complex binding
GO:0047747	cholate-CoA ligase activity

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0006642	triglyceride mobilization
GO:0006699	bile acid biosynthetic process
GO:0008152	metabolic process
GO:0008206	bile acid metabolic process
GO:0015721	bile acid and bile salt transport
GO:0015908	fatty acid transport
GO:0015911	plasma membrane long-chain fatty acid transport
GO:0044281	small molecule metabolic process
GO:0046951	ketone body biosynthetic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0009925	basal plasma membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex