InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC27A5

Summary

InnateDB Gene

IDBG-73443.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC27A5

Gene Name

solute carrier family 27 (fatty acid transporter), member 5

Synonyms

ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5; FATP5; VLACSR; VLCS-H2; VLCSH2

Species

Homo sapiens

Ensembl Gene

ENSG00000083807

Encoded Proteins

IDBP-73445

solute carrier family 27 (fatty acid transporter), member 5

IDBP-761220

IDBP-761162

IDBP-763667

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:58479512-58512413

Strand

Reverse strand

Band

q13.43

Transcripts

ENST00000263093	ENSP00000263093
ENST00000593745
ENST00000594786	ENSP00000471065
ENST00000601997
ENST00000594683
ENST00000595851	ENSP00000469512
ENST00000599700
ENST00000601355	ENSP00000470368

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005524	ATP binding
GO:0015245	fatty acid transporter activity
GO:0031957	very long-chain fatty acid-CoA ligase activity
GO:0032403	protein complex binding
GO:0047747	cholate-CoA ligase activity

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0006642	triglyceride mobilization
GO:0006699	bile acid biosynthetic process
GO:0008152	metabolic process
GO:0008206	bile acid metabolic process
GO:0015721	bile acid and bile salt transport
GO:0015908	fatty acid transport
GO:0015911	plasma membrane long-chain fatty acid transport
GO:0044281	small molecule metabolic process
GO:0046951	ketone body biosynthetic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0009925	basal plasma membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030382

View Gene Order

ENSBTAG00000015164

Not yet available

Pathways

NETPATH

REACTOME

REACT_11053

Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway

REACT_11041

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway

REACT_11054

Synthesis of bile acids and bile salts pathway

REACT_11042

Recycling of bile acids and salts pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_11040

Bile acid and bile salt metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa03320

PPAR signaling pathway pathway

hsa00120

Primary bile acid biosynthesis pathway

hsa04976

Bile secretion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.292177 Hs.610209

RefSeq

NM_012254

HUGO

OMIM

CCDS

CCDS12983

HPRD

04499

IMGT

EMBL

GenPept

RNA Seq Atlas