InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UTS2R

Summary

InnateDB Protein

IDBP-73506.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UTS2R

Protein Name

urotensin 2 receptor

Synonyms

GPR14; UR-2-R; UTR; UTR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000323516

InnateDB Gene

IDBG-73504 (UTS2R)

Protein Structure

UniProt Annotation

Function

High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system. {ECO:0000269PubMed:14550283}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Most abundant expression in the heart and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001604	urotensin II receptor activity
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0003105	negative regulation of glomerular filtration
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008015	blood circulation
GO:0010841	positive regulation of circadian sleep/wake cycle, wakefulness
GO:0030307	positive regulation of cell growth
GO:0035811	negative regulation of urine volume
GO:0035814	negative regulation of renal sodium excretion
GO:0042312	regulation of vasodilation
GO:0042493	response to drug
GO:0045766	positive regulation of angiogenesis
GO:0045776	negative regulation of blood pressure
GO:0045777	positive regulation of blood pressure
GO:0045907	positive regulation of vasoconstriction
GO:0046005	positive regulation of circadian sleep/wake cycle, REM sleep
GO:0048146	positive regulation of fibroblast proliferation