InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AMICA1

Summary

InnateDB Protein

IDBP-73538.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AMICA1

Protein Name

adhesion molecule, interacts with CXADR antigen 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000292067

InnateDB Gene

IDBG-73536 (AMICA1)

Protein Structure

UniProt Annotation

Function

Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T- cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. {ECO:0000269PubMed:12869515, ECO:0000269PubMed:15800062, ECO:0000269PubMed:18948633, ECO:0000269PubMed:19064666}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Cell junction. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts.

Disease Associations

Tissue Specificity

Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level). {ECO:0000269PubMed:12869515, ECO:0000269PubMed:18948633, ECO:0000269PubMed:19064666}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0007157	heterophilic cell-cell adhesion
GO:0007596	blood coagulation
GO:0030593	neutrophil chemotaxis
GO:0035696	monocyte extravasation
GO:0046629	gamma-delta T cell activation
GO:0050776	regulation of immune response
GO:0050900	leukocyte migration
GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing
GO:0072672	neutrophil extravasation