InnateDB Protein
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IDBP-73540.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AMICA1
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Protein Name
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adhesion molecule, interacts with CXADR antigen 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000348635
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InnateDB Gene
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IDBG-73536 (AMICA1)
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Protein Structure
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Function |
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T- cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. {ECO:0000269PubMed:12869515, ECO:0000269PubMed:15800062, ECO:0000269PubMed:18948633, ECO:0000269PubMed:19064666}.
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Subcellular Localization |
Cell membrane; Single-pass type I membrane protein. Cell junction. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts.
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Disease Associations |
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Tissue Specificity |
Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level). {ECO:0000269PubMed:12869515, ECO:0000269PubMed:18948633, ECO:0000269PubMed:19064666}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003599
Immunoglobulin subtype
IPR007110
Immunoglobulin-like domain
IPR013106
Immunoglobulin V-set domain
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PFAM |
PF07686
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PRINTS |
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PIRSF |
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SMART |
SM00409
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TIGRFAMs |
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Modification |
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SwissProt |
Q86YT9
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PhosphoSite |
PhosphoSite-Q86YT9
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TrEMBL |
E9PNS8
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UniProt Splice Variant |
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Entrez Gene |
120425
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UniGene |
Hs.657856
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RefSeq |
NP_001091996
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HUGO |
HGNC:19084
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OMIM |
609770
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CCDS |
CCDS41723
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HPRD |
16482
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IMGT |
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EMBL |
AJ515553
AK090409
AK094399
AP002800
AY093686
AY138965
AY358362
BC100797
EF444945
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GenPept |
AAI00798
AAM15730
AAN52117
AAQ88728
ACA05929
ACA05930
BAC03390
BAC04347
CAD56620
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