InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MPZL2

Summary

InnateDB Protein

IDBP-73589.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MPZL2

Protein Name

myelin protein zero-like 2

Synonyms

EVA; EVA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000278937

InnateDB Gene

IDBG-73587 (MPZL2)

Protein Structure

UniProt Annotation

Function

Mediates homophilic cell-cell adhesion.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in thymocytes and thymic stromal cells; expression elevated in some T-cell leukemias.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007156	homophilic cell adhesion
GO:0009653	anatomical structure morphogenesis
GO:0016337	single organismal cell-cell adhesion
GO:0033077	T cell differentiation in thymus

Cellular Component

GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000920 Myelin P0 protein like
IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain

PFAM

PF07686

PRINTS

PR00213

PIRSF

SMART

SM00406
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt