InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBQLN1

Summary

InnateDB Protein

IDBP-73624.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBQLN1

Protein Name

ubiquilin 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000257468

InnateDB Gene

IDBG-73620 (UBQLN1)

Protein Structure

UniProt Annotation

Function

Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors. Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:23979357}. Nucleus {ECO:0000269PubMed:23979357}. Note=Detected in neuronal processes and at synapses (By similarity). Detected in cytosolic puncta that may correspond to autophagosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed throughout the brain; detected in neurons and in neuropathological lesions, such as neurofibrillary tangles and Lewy bodies. Highly expressed in heart, placenta, pancreas, lung, liver, skeletal muscle and kidney. {ECO:0000269PubMed:11076969, ECO:0000269PubMed:11853878}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 360 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	360 [view]
Protein-Protein	356 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0019900	kinase binding

Biological Process

GO:0031396	regulation of protein ubiquitination
GO:0034976	response to endoplasmic reticulum stress
GO:0045087	innate immune response (InnateDB)
GO:0071456	cellular response to hypoxia
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR000626 Ubiquitin-like
IPR006636 Heat shock chaperonin-binding
IPR009060 UBA-like
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR016024 Armadillo-type fold
IPR022617 Rad60/SUMO-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00627
PF00240
PF14560
PF11976

PRINTS

PIRSF

SMART

SM00213
SM00727
SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UMX0