InnateDB Protein
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IDBP-74028.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GHRH
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Protein Name
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growth hormone releasing hormone
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Synonyms
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GHRF; GRF; INN;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000362713
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InnateDB Gene
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IDBG-74024 (GHRH)
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Protein Structure
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|
Function |
GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
|
Protein-Protein |
5
[view]
|
Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
|
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Predicted by orthology |
Total |
1 [view]
|
|
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Molecular Function |
Accession |
GO Term |
GO:0005179
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hormone activity
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GO:0016608
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growth hormone-releasing hormone activity
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GO:0031770
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growth hormone-releasing hormone receptor binding
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Biological Process |
GO:0007189
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adenylate cyclase-activating G-protein coupled receptor signaling pathway
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GO:0007267
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cell-cell signaling
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GO:0008284
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positive regulation of cell proliferation
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GO:0019933
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cAMP-mediated signaling
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GO:0021984
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adenohypophysis development
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GO:0030252
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growth hormone secretion
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GO:0030819
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positive regulation of cAMP biosynthetic process
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GO:0032094
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response to food
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GO:0040018
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positive regulation of multicellular organism growth
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GO:0043568
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positive regulation of insulin-like growth factor receptor signaling pathway
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GO:0046005
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positive regulation of circadian sleep/wake cycle, REM sleep
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GO:0060124
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positive regulation of growth hormone secretion
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Cellular Component |
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PDB ID |
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InterPro |
IPR000532
Glucagon/GIP/secretin/VIP
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PFAM |
PF00123
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PRINTS |
PR00275
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PIRSF |
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SMART |
SM00070
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TIGRFAMs |
|
Modification |
|
SwissProt |
P01286
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PhosphoSite |
PhosphoSite-P01286
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
2691
|
UniGene |
Hs.37023
|
RefSeq |
NP_001171660
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HUGO |
HGNC:4265
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OMIM |
139190
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CCDS |
CCDS54460
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HPRD |
11752
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IMGT |
|
EMBL |
AL031659
BC098109
BC098161
BC099727
L00134
L00135
L00136
L00137
L29177
X00094
|
GenPept |
AAA52608
AAA52609
AAH98109
AAH98161
AAH99727
CAA24955
CAA24956
CAB41762
CAI42673
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