InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GHRH

Summary

InnateDB Protein

IDBP-74030.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GHRH

Protein Name

growth hormone releasing hormone

Synonyms

GHRF; GRF; INN;

Species

Homo sapiens

Ensembl Protein

ENSP00000237527

InnateDB Gene

IDBG-74024 (GHRH)

Protein Structure

UniProt Annotation

Function

GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0016608	growth hormone-releasing hormone activity
GO:0031770	growth hormone-releasing hormone receptor binding

Biological Process

GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0019933	cAMP-mediated signaling
GO:0021984	adenohypophysis development
GO:0030252	growth hormone secretion
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032094	response to food
GO:0040018	positive regulation of multicellular organism growth
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0046005	positive regulation of circadian sleep/wake cycle, REM sleep
GO:0060124	positive regulation of growth hormone secretion