InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EFNB1

Summary

InnateDB Protein

IDBP-74052.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EFNB1

Protein Name

ephrin-B1

Synonyms

CFND; CFNS; EFB1; EFL3; Elk-L; EPLG2; LERK2;

Species

Homo sapiens

Ensembl Protein

ENSP00000204961

InnateDB Gene

IDBG-74050 (EFNB1)

Protein Structure

UniProt Annotation

Function

Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250}.Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to the receptor tyrosine kinases EPHB3 (preferred), EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Craniofrontonasal syndrome (CFNS) [MIM:304110]: X-linked inherited syndrome characterized by hypertelorism, coronal synostosis with brachycephaly, downslanting palpebral fissures, clefting of the nasal tip, joint anomalies, longitudinally grooved fingernails and other digital anomalies. {ECO:0000269PubMed:15124102, ECO:0000269PubMed:15166289, ECO:0000269PubMed:15959873}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Heart, placenta, lung, liver, skeletal muscle, kidney, pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0001755	neural crest cell migration
GO:0007155	cell adhesion
GO:0007267	cell-cell signaling
GO:0007411	axon guidance
GO:0009880	embryonic pattern specification
GO:0042102	positive regulation of T cell proliferation
GO:0048013	ephrin receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0045121	membrane raft
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome