InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PJA1

Summary

InnateDB Protein

IDBP-74075.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PJA1

Protein Name

praja ring finger 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355014

InnateDB Gene

IDBG-74069 (PJA1)

Protein Structure

UniProt Annotation

Function

Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting. {ECO:0000250, ECO:0000269PubMed:12036302}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in various regions of the brain including the cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Highest levels in the cerebral cortex. {ECO:0000269PubMed:12036302}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding