InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC28A3

Summary

InnateDB Protein

IDBP-74169.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC28A3

Protein Name

solute carrier family 28 (sodium-coupled nucleoside transporter), member 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000365413

InnateDB Gene

IDBG-74167 (SLC28A3)

Protein Structure

UniProt Annotation

Function

Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine. {ECO:0000269PubMed:11032837, ECO:0000269PubMed:16446384, ECO:0000269PubMed:17140564}.

Subcellular Localization

Isoform 1: Cell membrane; Multi-pass membrane protein.Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in pancreas, bone marrow, trachea, mammary gland, liver, prostate, and regions of intestine, brain, lung, placenta, testis, kidney, and heart. {ECO:0000269PubMed:11032837}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001882	nucleoside binding
GO:0005415	nucleoside:sodium symporter activity
GO:0015389	pyrimidine- and adenine-specific:sodium symporter activity
GO:0015390	purine-specific nucleoside:sodium symporter activity

Biological Process

GO:0006810	transport
GO:0006863	purine nucleobase transport
GO:0015855	pyrimidine nucleobase transport
GO:0015860	purine nucleoside transmembrane transport
GO:0015864	pyrimidine nucleoside transport
GO:0055085	transmembrane transport
GO:0072531	pyrimidine-containing compound transmembrane transport

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002668 Concentrative nucleoside transporter N-terminal domain
IPR011642 Nucleoside recognition Gate
IPR011657 Concentrative nucleoside transporter C-terminal domain
IPR018270 Concentrative nucleoside transporter, metazoan/bacterial

PFAM

PF01773
PF07670
PF07662

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9HAS3

PhosphoSite