InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Usp2

Summary

InnateDB Protein

IDBP-741756.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Usp2

Protein Name

Synonyms

B930035K21Rik; Ubp41;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000135018

InnateDB Gene

IDBG-155467 (Usp2)

Protein Structure

UniProt Annotation

Function

Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 2 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14686789}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. {ECO:0000250}.Isoform 2: Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in heart, liver, kidney, pancreas and to a lower extent in skeletal muscle, brain and testis (at protein level). Expressed in testis, brain, heart and skeletal muscle. {ECO:0000269PubMed:14686789}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004221	ubiquitin thiolesterase activity
GO:0008234	cysteine-type peptidase activity
GO:0030332	cyclin binding
GO:0031625	ubiquitin protein ligase binding
GO:0036459	ubiquitinyl hydrolase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007049	cell cycle
GO:0007517	muscle organ development
GO:0016579	protein deubiquitination
GO:0045931	positive regulation of mitotic cell cycle
GO:0048642	negative regulation of skeletal muscle tissue development
GO:0048643	positive regulation of skeletal muscle tissue development
GO:0050821	protein stabilization