InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnmt1

Summary

InnateDB Protein

IDBP-741871.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnmt1

Protein Name

Synonyms

Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1; Met1; MommeD2; MTase;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136982

InnateDB Gene

IDBG-138141 (Dnmt1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 96 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	36 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	96 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0003886	DNA (cytosine-5-)-methyltransferase activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008270	zinc ion binding
GO:0008327	methyl-CpG binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006306	DNA methylation
GO:0010468	regulation of gene expression
GO:0042127	regulation of cell proliferation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0071230	cellular response to amino acid stimulus
GO:0090116	C-5 methylation of cytosine

Cellular Component

GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005657	replication fork

Protein Structure and Domains

PDB ID

MGI:94912

InterPro

IPR001025 Bromo adjacent homology (BAH) domain
IPR001525 C-5 cytosine methyltransferase
IPR002857 Zinc finger, CXXC-type
IPR017198 DNA (cytosine-5)-methyltransferase 1, eukaryote
IPR022702 DNA (cytosine-5)-methyltransferase 1, replication foci domain
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF01426
PF00145
PF02008
PF12047

PRINTS

PR00105

PIRSF

PIRSF037404

SMART

SM00439

TIGRFAMs

Post-translational Modifications

Modification

Cross-References