InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nptn

Summary

InnateDB Protein

IDBP-742634.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nptn

Protein Name

Synonyms

AW554172; Sdfr1; SDR-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000135199

InnateDB Gene

IDBG-172134 (Nptn)

Protein Structure

UniProt Annotation

Function

Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Enriched at postsynaptic density. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 are widely expressed with variable levels in brain. Isoform 1 is expressed in cerebellum and midbrain. Isoform 1 and isoform 2 are expressed in cerebral cortex, hipoccampus and striatum. Isoform 2 is more abundant in the cerebral cortex than isoform 1. {ECO:0000269PubMed:8938438, ECO:0000269Ref.5}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005105	type 1 fibroblast growth factor receptor binding
GO:0005515	protein binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0007156	homophilic cell adhesion
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0010976	positive regulation of neuron projection development
GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway
GO:0048170	positive regulation of long-term neuronal synaptic plasticity
GO:0060291	long-term synaptic potentiation

Cellular Component

GO:0016021	integral component of membrane
GO:0042734	presynaptic membrane

Protein Structure and Domains

PDB ID

MGI:108077

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P97300