InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HINFP

Summary

InnateDB Protein

IDBP-74317.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HINFP

Protein Name

histone H4 transcription factor

Synonyms

HiNF-P; MIZF; ZNF743;

Species

Homo sapiens

Ensembl Protein

ENSP00000318085

InnateDB Gene

IDBG-74315 (HINFP)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter. {ECO:0000269PubMed:11553631, ECO:0000269PubMed:14585971, ECO:0000269PubMed:14752047, ECO:0000269PubMed:15988025, ECO:0000269PubMed:17163457, ECO:0000269PubMed:17974976, ECO:0000269PubMed:18850719}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11553631, ECO:0000269PubMed:14585971, ECO:0000269PubMed:15988025, ECO:0000269PubMed:18850719}. Note=Associated with discrete nuclear foci.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta and liver. {ECO:0000269PubMed:11553631}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0042393	histone binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0001701	in utero embryonic development
GO:0006281	DNA repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0045184	establishment of protein localization
GO:0045445	myoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated