InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOSTRIN

Summary

InnateDB Protein

IDBP-74327.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOSTRIN

Protein Name

nitric oxide synthase trafficker

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000318921

InnateDB Gene

IDBG-74325 (NOSTRIN)

Protein Structure

UniProt Annotation

Function

Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. {ECO:0000269PubMed:12446846, ECO:0000269PubMed:16234328, ECO:0000269PubMed:16807357}.

Subcellular Localization

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Note=Enriched in selected actin structures.

Disease Associations

Tissue Specificity

Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over- expressed in placenta from women with pre-eclampsia (at protein level). {ECO:0000269PubMed:12446846, ECO:0000269PubMed:15847871}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006897	endocytosis
GO:0007165	signal transduction
GO:0044281	small molecule metabolic process
GO:0046209	nitric oxide metabolic process
GO:0050999	regulation of nitric-oxide synthase activity