Version 5.4
Homo sapiens Protein: SPC25
Summary
InnateDB Protein IDBP-74340.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPC25
Protein Name SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000282074
InnateDB Gene IDBG-74338 (SPC25)
Protein Structure
UniProt Annotation
Function Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. {ECO:0000269PubMed:14699129, ECO:0000269PubMed:14738735}.
Subcellular Localization Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007052 mitotic spindle organization
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005829 cytosol
GO:0031262 Ndc80 complex
Protein Structure and Domains
PDB ID
InterPro IPR013255 Chromosome segregation protein Spc25
PFAM PF08234
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HBM1
PhosphoSite PhosphoSite-Q9HBM1
TrEMBL C9JW94
UniProt Splice Variant
Entrez Gene 57405
UniGene Hs.421956
RefSeq NP_065726
HUGO HGNC:24031
OMIM 609395
CCDS CCDS2229
HPRD 15465
IMGT
EMBL AC069137 AF225416 AK291093 AY456388 BC022255 CH471058 CR457197
GenPept AAG09718 AAH22255 AAR88652 AAY24098 BAF83782 CAG33478 EAX11289 EAX11290

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca