Version 5.4
Homo sapiens Gene: SPC25
Summary
InnateDB Gene IDBG-74338.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPC25
Gene Name SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000152253
Encoded Proteins
IDBP-74340
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
IDBP-387297
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:168834132-168913371
Strand Reverse strand
Band q31.1
Transcripts
ENST00000282074 ENSP00000282074
ENST00000451987 ENSP00000393322
ENST00000479309
ENST00000472216
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007052 mitotic spindle organization
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005829 cytosol
GO:0031262 Ndc80 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005233
View Gene Order
ENSBTAG00000010048
Not yet available
Pathways
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.421956
RefSeq NM_020675
HUGO
OMIM
CCDS CCDS2229
HPRD 15465
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca