Version 5.4
Mus musculus Protein: Rapgef3
Summary
InnateDB Protein IDBP-743709.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rapgef3
Protein Name
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000135317
InnateDB Gene IDBG-178771 (Rapgef3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0017034 Rap guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0032486 Rap protein signal transduction
GO:0032854 positive regulation of Rap GTPase activity
GO:0045766 positive regulation of angiogenesis
GO:0051496 positive regulation of stress fiber assembly
GO:0061028 establishment of endothelial barrier
GO:0071320 cellular response to cAMP
GO:2000249 regulation of actin cytoskeleton reorganization
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID MGI:2441741
InterPro IPR001895 Guanine-nucleotide dissociation stimulator CDC25
IPR023578 Ras guanine nucleotide exchange factor, domain
PFAM PF00617
PRINTS
PIRSF
SMART SM00147
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL H3BKA8
UniProt Splice Variant
Entrez Gene 223864
UniGene Mm.24028
RefSeq
MGI ID
MGI Symbol Rapgef3
OMIM
CCDS
HPRD
IMGT
EMBL AC104225
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca