Version 5.4
Mus musculus Gene: Rapgef3
Summary
InnateDB Gene IDBG-178771.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rapgef3
Gene Name Rap guanine nucleotide exchange factor (GEF) 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000022469
Encoded Proteins
IDBP-541394
Rap guanine nucleotide exchange factor (GEF) 3
IDBP-536828
Rap guanine nucleotide exchange factor (GEF) 3
IDBP-537174
Rap guanine nucleotide exchange factor (GEF) 3
IDBP-743709
IDBP-539154
Rap guanine nucleotide exchange factor (GEF) 3
IDBP-539139
Rap guanine nucleotide exchange factor (GEF) 3
IDBP-540613
Rap guanine nucleotide exchange factor (GEF) 3
IDBP-532310
Rap guanine nucleotide exchange factor (GEF) 3
IDBP-744191
IDBP-743756
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079337:
Gene Information
Type Protein coding
Genomic Location Chromosome 15:97744770-97767972
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000129223 ENSMUSP00000118148
ENSMUST00000128775 ENSMUSP00000120126
ENSMUST00000126854 ENSMUSP00000116426
ENSMUST00000134885 ENSMUSP00000135317
ENSMUST00000125002
ENSMUST00000123397
ENSMUST00000155810
ENSMUST00000146214
ENSMUST00000134371 ENSMUSP00000122746
ENSMUST00000153241
ENSMUST00000153464
ENSMUST00000149419 ENSMUSP00000122285
ENSMUST00000146620 ENSMUSP00000116673
ENSMUST00000142196
ENSMUST00000135080 ENSMUSP00000117337
ENSMUST00000177352 ENSMUSP00000135238
ENSMUST00000175894 ENSMUSP00000135194
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0008603 cAMP-dependent protein kinase regulator activity
GO:0017034 Rap guanyl-nucleotide exchange factor activity
GO:0030552 cAMP binding
Biological Process
GO:0001525 angiogenesis
GO:0007264 small GTPase mediated signal transduction
GO:0032486 Rap protein signal transduction
GO:0032854 positive regulation of Rap GTPase activity
GO:0035556 intracellular signal transduction
GO:0043087 regulation of GTPase activity
GO:0045766 positive regulation of angiogenesis
GO:0045859 regulation of protein kinase activity
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051496 positive regulation of stress fiber assembly
GO:0061028 establishment of endothelial barrier
GO:0071320 cellular response to cAMP
GO:2000249 regulation of actin cytoskeleton reorganization
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005952 cAMP-dependent protein kinase complex
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000079337
View Gene Order
ENSBTAG00000006828
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_217323
Integration of energy metabolism pathway
REACT_188937
Metabolism pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_263148
Regulation of insulin secretion pathway
REACT_237855
Rap1 signalling pathway
REACT_229531
Adaptive Immune System pathway
REACT_188257
Signal Transduction pathway
REACT_246176
Integrin alphaIIb beta3 signaling pathway
REACT_249309
Platelet Aggregation (Plug Formation) pathway
REACT_248547
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
KEGG
mmu04720
Long-term potentiation pathway
mmu04670
Leukocyte transendothelial migration pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23898
Rap1 signalling pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_18274
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_111217
Metabolism pathway
REACT_604
Hemostasis pathway
KEGG
hsa04720
Long-term potentiation pathway
hsa04670
Leukocyte transendothelial migration pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.24028
RefSeq NM_001177810 NM_001177811 NM_144850 XM_006520874 XM_006520875 XM_006520876 XM_006520877 XM_006520878
OMIM
CCDS CCDS37187 CCDS49713 CCDS49714
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca