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InnateDB Protein
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IDBP-743854.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Osmr
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Protein Name
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Synonyms
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OSMRB;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000135204
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InnateDB Gene
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IDBG-128241 (Osmr)
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Protein Structure
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| Function |
Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
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| Disease Associations |
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| Tissue Specificity |
Widely expressed. Expressed at highest levels in the lung, heart, thymus and spleen. {ECO:0000269PubMed:9584176, ECO:0000269PubMed:9920829}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
2
[view]
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| Protein-Protein |
2
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
6 [view]
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Molecular Function |
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| Biological Process |
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GO:0007166
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cell surface receptor signaling pathway
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GO:0038165
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oncostatin-M-mediated signaling pathway
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| Cellular Component |
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| PDB ID |
MGI:1330819
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| InterPro |
IPR003961
Fibronectin, type III
IPR011249
Metalloenzyme, LuxS/M16 peptidase-like
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| PFAM |
PF00041
PF01108
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| PRINTS |
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| PIRSF |
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| SMART |
SM00060
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| TIGRFAMs |
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| Modification |
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| SwissProt |
O70458
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| PhosphoSite |
PhosphoSite-O70458
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| TrEMBL |
Q3TRK8
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| UniProt Splice Variant |
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| Entrez Gene |
18414
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| UniGene |
Mm.10760
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Osmr
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AB015978
AF058805
AK162684
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| GenPept |
AAC40122
BAA33725
BAE37021
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Version 5.4