Version 5.4
Mus musculus Gene: Osmr
Summary
InnateDB Gene IDBG-128241.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Osmr
Gene Name oncostatin M receptor
Synonyms OSMRB
Species Mus musculus
Ensembl Gene ENSMUSG00000022146
Encoded Proteins
IDBP-128243
oncostatin M receptor
IDBP-743854
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145623:
This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:6813577-6874969
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000022746 ENSMUSP00000022746
ENSMUST00000176554
ENSMUST00000177478
ENSMUST00000177263
ENSMUST00000175862
ENSMUST00000176826 ENSMUSP00000135204
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004924 oncostatin-M receptor activity
GO:0005515 protein binding
GO:0019838 growth factor binding
GO:0046872 metal ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0034097 response to cytokine
GO:0038165 oncostatin-M-mediated signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0005900 oncostatin-M receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145623
View Gene Order
ENSBTAG00000033107
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_114
Oncostatin_M pathway
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.10760
RefSeq NM_011019 XM_006519973 XM_006519974 XM_006519975 XM_006519976 XM_006519977
OMIM
CCDS CCDS27368
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca