InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIF4A

Summary

InnateDB Protein

IDBP-74425.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF4A

Protein Name

kinesin family member 4A

Synonyms

KIF4; KIF4G1; MRX100;

Species

Homo sapiens

Ensembl Protein

ENSP00000363524

InnateDB Gene

IDBG-74423 (KIF4A)

Protein Structure

UniProt Annotation

Function

Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization. {ECO:0000269PubMed:15297875, ECO:0000269PubMed:15625105}.

Subcellular Localization

Nucleus matrix. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome. Note=Not present in the nucleolus. In early mitosis, associated with the mitotic spindle, in anaphase, localized to the spindle midzone and, in telophase and cytokinesis, to the midbody. In late cytokinesis, found in the center of the midbody. Associated with chromosomes at all stages of mitosis.

Disease Associations

Tissue Specificity

Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow. Lower levels are found in heart, testis, kidney, colon and lung. {ECO:0000269PubMed:10978527}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0008017	microtubule binding

Biological Process

GO:0006996	organelle organization
GO:0007018	microtubule-based movement
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008089	anterograde axon cargo transport
GO:0008152	metabolic process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0005876	spindle microtubule
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0030496	midbody