InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KIF4A

Summary

InnateDB Gene

IDBG-74423.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF4A

Gene Name

kinesin family member 4A

Synonyms

KIF4; KIF4G1; MRX100

Species

Homo sapiens

Ensembl Gene

ENSG00000090889

Encoded Proteins

IDBP-74425

kinesin family member 4A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:70290090-70420832

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000374403	ENSP00000363524
ENST00000485406

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0008017	microtubule binding

Biological Process

GO:0006996	organelle organization
GO:0007018	microtubule-based movement
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008089	anterograde axon cargo transport
GO:0008152	metabolic process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0005876	spindle microtubule
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0030496	midbody