InnateDB Protein
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IDBP-744650.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SCAMP5
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Protein Name
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000455313
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InnateDB Gene
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IDBG-22989 (SCAMP5)
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Protein Structure
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Function |
Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway. {ECO:0000269PubMed:19234194}.
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Subcellular Localization |
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Mainly localizes in Golgi apparatus membrane. Upon calcium- triggered exocytosis, it translocates to the cell membrane. Highly enriched in synaptic vesicles (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed both by neuronal and non-neuronal tissues. Expressed in brain, stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and in the different parts of brain. In thyroid tissues, it is expressed by the follicular epithelial cells. In the adrenal gland tissues it is detected in the zona fasciculata of the cortex region (at protein level). {ECO:0000269PubMed:19234194}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007273
SCAMP
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PFAM |
PF04144
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TAC9
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PhosphoSite |
PhosphoSite-Q8TAC9
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TrEMBL |
H3BTD1
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UniProt Splice Variant |
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Entrez Gene |
192683
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UniGene |
Hs.627551
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RefSeq |
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HUGO |
HGNC:30386
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OMIM |
613766
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CCDS |
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HPRD |
18020
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IMGT |
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EMBL |
AC015720
AF495715
AK056438
AK126940
AK127480
AK301505
AL834226
BC024700
CH471136
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GenPept |
AAH24700
AAM18052
BAG51709
BAG54404
BAG54511
BAH13498
CAD38904
EAW99277
EAW99278
EAW99280
EAW99283
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