InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RPRD1B

Summary

InnateDB Protein

IDBP-74560.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPRD1B

Protein Name

regulation of nuclear pre-mRNA domain containing 1B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362532

InnateDB Gene

IDBG-74558 (RPRD1B)

Protein Structure

UniProt Annotation

Function

Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000269PubMed:22231121, ECO:0000269PubMed:22264791}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:22264791}.

Disease Associations

Tissue Specificity

Preferentially expressed in a range of tumor tissues including colon, lung, liver, breast, prostate, stomach, uterine endometrium and cervical cancers with higher levels in tumors than in adjacent non-tumor tissue (at protein level). {ECO:0000269PubMed:22264791}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.

Experimentally validated
Total	41 [view]
Protein-Protein	40 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000993	RNA polymerase II core binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0010564	regulation of cell cycle process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070940	dephosphorylation of RNA polymerase II C-terminal domain