InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EHD4

Summary

InnateDB Protein

IDBP-7458.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EHD4

Protein Name

EH-domain containing 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000220325

InnateDB Gene

IDBG-7456 (EHD4)

Protein Structure

UniProt Annotation

Function

Plays a role in early endosomal transport. {ECO:0000269PubMed:17233914, ECO:0000269PubMed:18331452}.

Subcellular Localization

Cell membrane {ECO:0000250}. Early endosome membrane {ECO:0000269PubMed:18331452}; Peripheral membrane protein {ECO:0000269PubMed:18331452}. Recycling endosome membrane {ECO:0000269PubMed:18331452}; Peripheral membrane protein {ECO:0000269PubMed:18331452}.

Disease Associations

Tissue Specificity

Highly expressed in pancreas and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003924	GTPase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006907	pinocytosis
GO:0030100	regulation of endocytosis
GO:0032456	endocytic recycling
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051260	protein homooligomerization
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031901	early endosome membrane
GO:0048471	perinuclear region of cytoplasm
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome