Version 5.4
Homo sapiens Gene: EHD4
Summary
InnateDB Gene IDBG-7456.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EHD4
Gene Name EH-domain containing 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000103966
Encoded Proteins
IDBP-7458
EH-domain containing 4
IDBP-813430
EH-domain containing 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 15:41895939-41972578
Strand Reverse strand
Band q15.1
Transcripts
ENST00000220325 ENSP00000220325
ENST00000569223
ENST00000612090 ENSP00000478504
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003924 GTPase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006907 pinocytosis
GO:0030100 regulation of endocytosis
GO:0032456 endocytic recycling
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051260 protein homooligomerization
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031901 early endosome membrane
GO:0048471 perinuclear region of cytoplasm
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027293
View Gene Order
ENSBTAG00000006792
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
mapktrkpathway
Trk receptor signaling mediated by the MAPK pathway
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
Cross-References
SwissProt Q9H223
TrEMBL A0A024R9N6
UniProt Splice Variant
Entrez Gene 30844
UniGene Hs.143703 Hs.598990 Hs.623519 Hs.713881
RefSeq NM_139265
HUGO HGNC:3245
OMIM 605892
CCDS CCDS10081
HPRD
IMGT
EMBL AF181265 AF307137 AF323924 AF454953 BC006287 BC051823 CH471125
GenPept AAF40472 AAG28784 AAH06287 AAH51823 AAK11599 AAL51079 EAW92525 EAW92526
RNA Seq Atlas 30844

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca