InnateDB Protein
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IDBP-746227.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IST1
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Protein Name
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Synonyms
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OLC1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000455860
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InnateDB Gene
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IDBG-41285 (IST1)
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Protein Structure
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Function |
Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. {ECO:0000269PubMed:19129479, ECO:0000269PubMed:19129480}.
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Subcellular Localization |
Cytoplasmic vesicle {ECO:0000269PubMed:19129479, ECO:0000269PubMed:19129480}. Note=Localizes to the midbody of dividing cells.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
23
[view]
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Protein-Protein |
23
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005061
Domain of unknown function DUF292, eukaryotic
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PFAM |
PF03398
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P53990
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PhosphoSite |
PhosphoSite-P53990
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TrEMBL |
H3BUI0
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UniProt Splice Variant |
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Entrez Gene |
9798
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UniGene |
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RefSeq |
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HUGO |
HGNC:28977
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OMIM |
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CCDS |
CCDS59272
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HPRD |
13784
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IMGT |
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EMBL |
AB097052
AC009127
AC010653
AK057258
AK293022
AK293040
AK297088
AK301918
BC000116
BC000430
BC004359
BC103745
D79996
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GenPept |
AAH00116
AAH00430
AAH04359
AAI03746
BAA11491
BAC77405
BAF85711
BAF85729
BAG51894
BAG59603
BAG63341
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