InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPN

Summary

InnateDB Protein

IDBP-746280.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPN

Protein Name

Synonyms

CD43; GALGP; GPL115; LSN;

Species

Homo sapiens

Ensembl Protein

ENSP00000455266

InnateDB Gene

IDBG-24512 (SPN)

Protein Structure

UniProt Annotation

Function

One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity

Biological Process

GO:0006935	chemotaxis
GO:0006955	immune response
GO:0006968	cellular defense response
GO:0007163	establishment or maintenance of cell polarity
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0042742	defense response to bacterium
GO:0050900	leukocyte migration