InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BPI

Summary

InnateDB Protein

IDBP-74656.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BPI

Protein Name

bactericidal/permeability-increasing protein

Synonyms

BPIFD1; rBPI;

Species

Homo sapiens

Ensembl Protein

ENSP00000262865

InnateDB Gene

IDBG-74654 (BPI)

Protein Structure

UniProt Annotation

Function

The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. {ECO:0000269PubMed:1937776, ECO:0000269PubMed:2722846}.

Subcellular Localization

Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.

Disease Associations

Tissue Specificity

Restricted to cells of the myeloid series.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0008289	lipid binding

Biological Process

GO:0006955	immune response
GO:0032715	negative regulation of interleukin-6 production
GO:0032717	negative regulation of interleukin-8 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0042742	defense response to bacterium
GO:0043031	negative regulation of macrophage activation
GO:0045087	innate immune response

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001124 Lipid-binding serum glycoprotein, C-terminal
IPR017942 Lipid-binding serum glycoprotein, N-terminal
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain

PFAM

PF02886
PF01273

PRINTS

PIRSF

SMART

SM00329
SM00328

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P17213