InnateDB Protein
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IDBP-74679.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ISCA1
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Protein Name
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iron-sulfur cluster assembly 1 homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000365159
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InnateDB Gene
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IDBG-74675 (ISCA1)
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Protein Structure
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Function |
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. {ECO:0000269PubMed:15262227, ECO:0000269PubMed:22323289}.
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Subcellular Localization |
Mitochondrion {ECO:0000269PubMed:15262227, ECO:0000269PubMed:22323289}.
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Disease Associations |
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Tissue Specificity |
Detected in cerebellum, kidney and heart. {ECO:0000269PubMed:15262227}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000361
FeS cluster biogenesis
IPR016092
FeS cluster insertion protein
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PFAM |
PF01521
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BUE6
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q5TBE2
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UniProt Splice Variant |
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Entrez Gene |
81689
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UniGene |
Hs.449291
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RefSeq |
NP_112202
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HUGO |
HGNC:28660
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OMIM |
611006
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CCDS |
CCDS35056
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HPRD |
17091
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IMGT |
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EMBL |
AF284752
AK055643
AK296093
AL137849
AL834356
AY015642
BC002675
BC071621
CH471089
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GenPept |
AAG40950
AAG59854
AAH02675
AAH71621
BAG51546
BAG58847
CAD39021
CAI14925
EAW62713
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