InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MBL2

Summary

InnateDB Protein

IDBP-74692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MBL2

Protein Name

mannose-binding lectin (protein C) 2, soluble

Synonyms

COLEC1; HSMBPC; MBL; MBL2D; MBP; MBP-C; MBP1; MBPD;

Species

Homo sapiens

Ensembl Protein

ENSP00000363079

InnateDB Gene

IDBG-74690 (MBL2)

Protein Structure

UniProt Annotation

Function

Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. {ECO:0000269PubMed:14515269}.

Subcellular Localization

Secreted {ECO:0000269PubMed:7982896}.

Disease Associations

Tissue Specificity

Plasma protein produced mainly in the liver. {ECO:0000269PubMed:18006063}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005537	mannose binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001867	complement activation, lectin pathway
GO:0006953	acute-phase response
GO:0006956	complement activation
GO:0006958	complement activation, classical pathway
GO:0006979	response to oxidative stress
GO:0008228	opsonization
GO:0042742	defense response to bacterium
GO:0044130	negative regulation of growth of symbiont in host
GO:0045087	innate immune response (InnateDB)
GO:0048525	negative regulation of viral process
GO:0050766	positive regulation of phagocytosis
GO:0050830	defense response to Gram-positive bacterium
GO:0051873	killing by host of symbiont cells