InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRTAM

Summary

InnateDB Protein

IDBP-74803.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRTAM

Protein Name

cytotoxic and regulatory T cell molecule

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000227348

InnateDB Gene

IDBG-74801 (CRTAM)

Protein Structure

UniProt Annotation

Function

Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. {ECO:0000250UniProtKB:Q149L7, ECO:0000269PubMed:15811952}.

Subcellular Localization

Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.

Disease Associations

Tissue Specificity

In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT and CD8 cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues. {ECO:0000269PubMed:10811014, ECO:0000269PubMed:15811952, ECO:0000269PubMed:16300832}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0002355	detection of tumor cell
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0008037	cell recognition
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0050715	positive regulation of cytokine secretion
GO:0050776	regulation of immune response
GO:0051606	detection of stimulus

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07679
PF07686
PF08205

PRINTS

PIRSF

SMART

SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95727