InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOXO4

Summary

InnateDB Protein

IDBP-74846.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXO4

Protein Name

forkhead box O4

Synonyms

AFX; AFX1; MLLT7;

Species

Homo sapiens

Ensembl Protein

ENSP00000342209

InnateDB Gene

IDBG-74840 (FOXO4)

Protein Structure

UniProt Annotation

Function

Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269PubMed:10217147, ECO:0000269PubMed:10783894, ECO:0000269PubMed:12761217, ECO:0000269PubMed:15126506, ECO:0000269PubMed:16054032, ECO:0000269PubMed:16964248, ECO:0000269PubMed:20874444, ECO:0000269PubMed:22972301}.

Subcellular Localization

Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.

Disease Associations

Note=A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with KMT2A/MLL1. The result is a rogue activator protein.

Tissue Specificity

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	31 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019899	enzyme binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007050	cell cycle arrest
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007517	muscle organ development
GO:0008285	negative regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0016525	negative regulation of angiogenesis
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048863	stem cell differentiation
GO:0051151	negative regulation of smooth muscle cell differentiation
GO:0070317	negative regulation of G0 to G1 transition