InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FOXO4

Summary

InnateDB Gene

IDBG-74840.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXO4

Gene Name

forkhead box O4

Synonyms

AFX; AFX1; MLLT7

Species

Homo sapiens

Ensembl Gene

ENSG00000184481

Encoded Proteins

IDBP-74842

forkhead box O4

IDBP-74846

forkhead box O4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:71096197-71103535

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000374259	ENSP00000363377
ENST00000341558	ENSP00000342209
ENST00000466874
ENST00000464598

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	31 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019899	enzyme binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007050	cell cycle arrest
GO:0007095	mitotic G2 DNA damage checkpoint
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007517	muscle organ development
GO:0008285	negative regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0016525	negative regulation of angiogenesis
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048863	stem cell differentiation
GO:0051151	negative regulation of smooth muscle cell differentiation
GO:0070317	negative regulation of G0 to G1 transition

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000042903

View Gene Order

ENSBTAG00000004879

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

NetPath_7

TGF_beta_Receptor pathway

NetPath_18

IL6 pathway

NetPath_21

RANKL pathway

REACTOME

KEGG

INOH

INOH website

Insulin receptor signaling pathway

PID NCI

foxopathway

FoxO family signaling

hdac_classiii_pathway

Signaling events mediated by HDAC Class III

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.239663 Hs.584654

RefSeq

NM_001170931 NM_005938

HUGO

OMIM

CCDS

CCDS43969 CCDS55440

HPRD

02070

IMGT

EMBL

GenPept

RNA Seq Atlas